Go to content
UR Home

An engineered IL-2 partial agonist promotes CD8+ T cell stemness

Mo, Fei ; Yu, Zhiya ; Li, Peng ; Oh, Jangsuk ; Spolski, Rosanne ; Zhao, Liang ; Glassman, Caleb R. ; Yamamoto, Tori N. ; Chen, Yun ; Golebiowski, Filip M. ; Hermans, Dalton ; Majri-Morrison, Sonia ; Picton, Lora K. ; Liao, Wei ; Ren, Min ; Zhuang, Xiaoxuan ; Mitra, Suman ; Lin, Jian-Xin ; Gattinoni, Luca ; Powell, Jonathan D. ; Restifo, Nicholas P. ; Garcia, K. Christopher ; Leonard, Warren J.


Adoptive transfer of antigen-specific T cells represents a major advance in cancer immunotherapy, with robust clinical outcomes in some patients(1). Both the number of transferred T cells and their differentiation state are critical determinants of effective responses(2,3). T cells can be expanded with T cell receptor (TCR)-mediated stimulation and interleukin-2, but this can lead to ...


Owner only: item control page
  1. Homepage UR

University Library

Publication Server


Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: datahub@ur.de
0941 943 -5707

Contact persons