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BACH2 enforces the transcriptional and epigenetic programs of stem-like CD8+ T cells

Yao, Chen ; Lou, Guohua ; Sun, Hong-Wei ; Zhu, Ziang ; Sun, Yi ; Chen, Zeyu ; Chauss, Daniel ; Moseman, E. Ashley ; Cheng, Jun ; D’Antonio, Marc A. ; Shi, Wangke ; Shi, Junwei ; Kometani, Kohei ; Kurosaki, Tomohiro ; Wherry, E. John ; Afzali, Behdad ; Gattinoni, Luca ; Zhu, Yuwen ; McGavern, Dorian B. ; O’Shea, John J. ; Schwartzberg, Pamela L. ; Wu, Tuoqi



Abstract

During chronic infection and cancer, a self-renewing CD8(+) T cell subset maintains long-term immunity and is critical to the effectiveness of immunotherapy. These stem-like CD8(+) T cells diverge from other CD8(+) subsets early after chronic viral infection. However, pathways guarding stem-like CD8(+) T cells against terminal exhaustion remain unclear. Here, we show that the gene encoding ...

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