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uPA‐PAI‐1 heteromerization promotes breast cancer progression by attracting tumorigenic neutrophils

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Uhl, Bernd ; A Mittmann, Laura ; Dominik, Julian ; Hennel, Roman ; Smiljanov, Bojan ; Haring, Florian ; B Schaubächer, Johanna ; Braun, Constanze ; Padovan, Lena ; Pick, Robert ; Canis, Martin ; Schulz, Christian ; Mack, Matthias ; Gutjahr, Ewgenija ; Sinn, Peter ; Heil, Jörg ; Steiger, Katja ; Kanse, Sandip M ; Weichert, Wilko ; Sperandio, Markus ; Lauber, Kirsten ; Krombach, Fritz ; Reichel, Christoph A
[img]License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 29 Feb 2024 12:29


High intratumoral levels of urokinase-type plasminogen activator (uPA)-plasminogen activator inhibitor-1 (PAI-1) heteromers predict impaired survival and treatment response in early breast cancer. The pathogenetic role of this protein complex remains obscure. Here, we demonstrate that heteromerization of uPA and PAI-1 multiplies the potential of the single proteins to attract pro-tumorigenic ...


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