uPA‐PAI‐1 heteromerization promotes breast cancer progression by attracting tumorigenic neutrophils

URN to cite this document:: urn:nbn:de:bvb:355-epub-566005
DOI to cite this document:: 10.5283/epub.56600

Uhl, Bernd ; A Mittmann, Laura ; Dominik, Julian ; Hennel, Roman ; Smiljanov, Bojan ; Haring, Florian ; B Schaubächer, Johanna ; Braun, Constanze ; Padovan, Lena ; Pick, Robert ; Canis, Martin ; Schulz, Christian ; Mack, Matthias ; Gutjahr, Ewgenija ; Sinn, Peter

; Heil, Jörg ; Steiger, Katja ; Kanse, Sandip M ; Weichert, Wilko ; Sperandio, Markus

; Lauber, Kirsten ; Krombach, Fritz ; Reichel, Christoph A

License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 29 Feb 2024 12:29

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Abstract

High intratumoral levels of urokinase-type plasminogen activator (uPA)-plasminogen activator inhibitor-1 (PAI-1) heteromers predict impaired survival and treatment response in early breast cancer. The pathogenetic role of this protein complex remains obscure. Here, we demonstrate that heteromerization of uPA and PAI-1 multiplies the potential of the single proteins to attract pro-tumorigenic ...