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Cellular Mechanisms of the Anti-Arrhythmic Effect of Cardiac PDE2 Overexpression

Wagner, Michael ; Sadek, Mirna S. ; Dybkova, Nataliya ; Mason, Fleur E. ; Klehr, Johann ; Firneburg, Rebecca ; Cachorro, Eleder ; Richter, Kurt ; Klapproth, Erik ; Kuenzel, Stephan R. ; Lorenz, Kristina ; Heijman, Jordi ; Dobrev, Dobromir ; El-Armouche, Ali ; Sossalla, Samuel ; Kämmerer, Susanne


Background: Phosphodiesterases (PDE) critically regulate myocardial cAMP and cGMP levels. PDE2 is stimulated by cGMP to hydrolyze cAMP, mediating a negative crosstalk between both pathways. PDE2 upregulation in heart failure contributes to desensitization to beta-adrenergic overstimulation. After isoprenaline (ISO) injections, PDE2 overexpressing mice (PDE2 OE) were protected against ventricular ...


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