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Treatment tapering and stopping in patients with rheumatoid arthritis in stable remission (RETRO): a multicentre, randomised, controlled, open-label, phase 3 trial

Tascilar, Koray ; Hagen, Melanie ; Kleyer, Arnd ; Simon, David ; Reiser, Michaela ; Hueber, Axel J. ; Manger, Bernhard ; Englbrecht, Matthias ; Finzel, Stephanie ; Tony, Hans-Peter ; Schuch, Florian ; Kleinert, Stefan ; Wendler, Joerg ; Ronneberger, Monika ; Figueiredo, Camille P. ; Cobra, Jayme F. ; Feuchtenberger, Martin ; Fleck, Martin ; Manger, Karin ; Ochs, Wolfgang ; Schmitt-Haendle, Matthias ; Lorenz, Hanns-Martin ; Nuesslein, Hubert ; Alten, Rieke ; Kruger, Klaus ; Henes, Joerg ; Schett, Georg ; Rech, Juergen


Background Owing to increasing remission rates, the management of patients with rheumatoid arthritis in sustained remission is of growing interest. The Rheumatoid Arthritis in Ongoing Remission (RETRO) study investigated tapering and withdrawal of disease-modifying antirheumatic drugs (DMARDs) in patients with rheumatoid arthritis in stable remission to test whether remission could be retained ...


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