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Cold exposure protects from neuroinflammation through immunologic reprogramming

Spiljar, Martina ; Steinbach, Karin ; Rigo, Dorothée ; Suárez-Zamorano, Nicolas ; Wagner, Ingrid ; Hadadi, Noushin ; Vincenti, Ilena ; Page, Nicolas ; Klimek, Bogna ; Rochat, Mary-Aude ; Kreutzfeldt, Mario ; Chevalier, Claire ; Stojanović, Ozren ; Bejuy, Olivia ; Colin, Didier ; Mack, Matthias ; Cansever, Dilay ; Greter, Melanie ; Merkler, Doron ; Trajkovski, Mirko


Autoimmunity is energetically costly, but the impact of a metabolically active state on immunity and immunemediated diseases is unclear. Ly6C(hi) monocytes are key effectors in CNS autoimmunity with an elusive role in priming naive autoreactive T cells. Here, we provide unbiased analysis of the immune changes in various compartments during cold exposure and show that this energetically costly ...


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