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The Interplay between S-Glutathionylation and Phosphorylation of Cardiac Troponin I and Myosin Binding Protein C in End-Stage Human Failing Hearts

Budde, Heidi ; Hassoun, Roua ; Tangos, Melina ; Zhazykbayeva, Saltanat ; Herwig, Melissa ; Varatnitskaya, Marharyta ; Sieme, Marcel ; Delalat, Simin ; Sultana, Innas ; Kolijn, Detmar ; Gömöri, Kamilla ; Jarkas, Muhammad ; Lódi, Mária ; Jaquet, Kornelia ; Kovács, Árpád ; Mannherz, Hans Georg ; Sequeira, Vasco ; Mügge, Andreas ; Leichert, Lars I. ; Sossalla, Samuel ; Hamdani, Nazha



Abstract

Oxidative stress is defined as an imbalance between the antioxidant defense system and the production of reactive oxygen species (ROS). At low levels, ROS are involved in the regulation of redox signaling for cell protection. However, upon chronical increase in oxidative stress, cell damage occurs, due to protein, DNA and lipid oxidation. Here, we investigated the oxidative modifications of ...

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