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Tumor restriction by type I collagen opposes tumor-promoting effects of cancer-associated fibroblasts

Bhattacharjee, Sonakshi ; Hamberger, Florian ; Ravichandra, Aashreya ; Miller, Maximilian ; Nair, Ajay ; Affo, Silvia ; Filliol, Aveline ; Chin, LiKang ; Savage, Thomas M. ; Yin, Deqi ; Wirsik, Naita Maren ; Mehal, Adam ; Arpaia, Nicholas ; Seki, Ekihiro ; Mack, Matthias ; Zhu, Di ; Sims, Peter A. ; Kalluri, Raghu ; Stanger, Ben Z. ; Olive, Kenneth P. ; Schmidt, Thomas ; Wells, Rebecca G. ; Mederacke, Ingmar ; Schwabe, Robert F.



Abstract

Cancer-associated fibroblasts (CAF) may exert tumor-promoting and tumor-suppressive functions, but the mechanisms underlying these opposing effects remain elusive. Here, we sought to understand these potentially opposing functions by interrogating functional relationships among CAF subtypes, their mediators, desmoplasia, and tumor growth in a wide range of tumor types metastasizing to the liver, ...

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