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Targeting clinical epigenetic reprogramming for chemoprevention of metabolic and viral hepatocellular carcinoma

Jühling, Frank ; Hamdane, Nourdine ; Crouchet, Emilie ; Li, Shen ; El Saghire, Houssein ; Mukherji, Atish ; Fujiwara, Naoto ; Oudot, Marine A ; Thumann, Christine ; Saviano, Antonio ; Roca Suarez, Armando Andres ; Goto, Kaku ; Masia, Ricard ; Sojoodi, Mozhdeh ; Arora, Gunisha ; Aikata, Hiroshi ; Ono, Atsushi ; Tabrizian, Parissa ; Schwartz, Myron ; Polyak, Stephen J ; Davidson, Irwin ; Schmidl, Christian ; Bock, Christoph ; Schuster, Catherine ; Chayama, Kazuaki ; Pessaux, Patrick ; Tanabe, Kenneth K ; Hoshida, Yujin ; Zeisel, Mirjam B ; Duong, François HT ; Fuchs, Bryan C ; Baumert, Thomas F



Abstract

Objective Hepatocellular carcinoma (HCC) is the fastest-growing cause of cancer-related mortality with chronic viral hepatitis and non-alcoholic steatohepatitis (NASH) as major aetiologies. Treatment options for HCC are unsatisfactory and chemopreventive approaches are absent. Chronic hepatitis C (CHC) results in epigenetic alterations driving HCC risk and persisting following cure. Here, we ...

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