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Genetic susceptibility to acute graft versus host disease in pediatric patients undergoing HSCT

Ansari, Marc ; Petrykey, Kateryna ; Rezgui, Mohamed Aziz ; Del Vecchio, Veronica ; Cortyl, Jacques ; Ameur, Milad ; Nava, Tiago ; Beaulieu, Patrick ; St-Onge, Pascal ; Mlakar, Simona Jurkovic ; Uppugunduri, Chakradhara Rao S. ; Théoret, Yves ; Bartelink, Imke H. ; Boelens, Jaap-Jan ; Bredius, Robbert G. M. ; Dalle, Jean-Hugues ; Lewis, Victor ; Kangarloo, Bill S. ; Corbacioglu, Selim ; Sinnett, Daniel ; Bittencourt, Henrique ; Krajinovic, Maja



Abstract

The most frequent complication of allogeneic hematopoietic stem cell transplantation is acute Graft versus Host Disease (aGVHD). Proliferation and differentiation of donor T cells initiate inflammatory response affecting the skin, liver, and gastrointestinal tract. Besides recipient-donor HLA disparities, disease type, and the conditioning regimen, variability in the non-HLA genotype have an ...

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