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Pan-protective anti-alphavirus human antibodies target a conserved E1 protein epitope

Kim, Arthur S. ; Kafai, Natasha M. ; Winkler, Emma S. ; Gilliland, Theron C. ; Cottle, Emily L. ; Earnest, James T. ; Jethva, Prashant N. ; Kaplonek, Paulina ; Shah, Aadit P. ; Fong, Rachel H. ; Davidson, Edgar ; Malonis, Ryan J. ; Quiroz, Jose A. ; Williamson, Lauren E. ; Vang, Lo ; Mack, Matthias ; Crowe, James E. ; Doranz, Benjamin J. ; Lai, Jonathan R. ; Alter, Galit ; Gross, Michael L. ; Klimstra, William B. ; Fremont, Daved H. ; Diamond, Michael S.



Abstract

Alphaviruses are emerging, mosquito-transmitted pathogens that cause musculoskeletal and neurological disease in humans. Although neutralizing antibodies that inhibit individual alphaviruses have been described, broadly reactive antibodies that protect against both arthritogenic and encephalitic alphaviruses have not been reported. Here, we identify DC2.112 and DC2.315, two pan-protective yet ...

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