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Angiotensin II receptor blocker intake associates with reduced markers of inflammatory activation and decreased mortality in patients with cardiovascular comorbidities and COVID-19 disease

Taniyama, Yoshiaki ; Cremer, Sebastian ; Pilgram, Lisa ; Berkowitsch, Alexander ; Stecher, Melanie ; Rieg, Siegbert ; Shumliakivska, Mariana ; Bojkova, Denisa ; Wagner, Julian Uwe Gabriel ; Aslan, Galip Servet ; Spinner, Christoph ; Luxán, Guillermo ; Hanses, Frank ; Dolff, Sebastian ; Piepel, Christiane ; Ruppert, Clemens ; Guenther, Andreas ; Rüthrich, Maria Madeleine ; Vehreschild, Jörg Janne ; Wille, Kai ; Haselberger, Martina ; Heuzeroth, Hanno ; Hansen, Arne ; Eschenhagen, Thomas ; Cinatl, Jindrich ; Ciesek, Sandra ; Dimmeler, Stefanie ; Borgmann, Stefan ; Zeiher, Andreas



Abstract

Aims Patients with cardiovascular comorbidities have a significantly increased risk for a critical course of COVID-19. As the SARS-CoV2 virus enters cells via the angiotensin-converting enzyme receptor II (ACE2), drugs which interact with the renin angiotensin aldosterone system (RAAS) were suspected to influence disease severity. Methods and results We analyzed 1946 consecutive patients with ...

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