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Epigenomic and transcriptional profiling identifies impaired glyoxylate detoxification in NAFLD as a risk factor for hyperoxaluria

Gianmoena, Kathrin ; Gasparoni, Nina ; Jashari, Adelina ; Gabrys, Philipp ; Grgas, Katharina ; Ghallab, Ahmed ; Nordström, Karl ; Gasparoni, Gilles ; Reinders, Jörg ; Edlund, Karolina ; Godoy, Patricio ; Schriewer, Alexander ; Hayen, Heiko ; Hudert, Christian A. ; Damm, Georg ; Seehofer, Daniel ; Weiss, Thomas S. ; Boor, Peter ; Anders, Hans-Joachim ; Motrapu, Manga ; Jansen, Peter ; Schiergens, Tobias S. ; Falk-Paulsen, Maren ; Rosenstiel, Philip ; Lisowski, Clivia ; Salido, Eduardo ; Marchan, Rosemarie ; Walter, Jörn ; Hengstler, Jan G. ; Cadenas, Cristina



Abstract

Epigenetic modifications (e.g. DNA methylation) in NAFLD and their contribution to disease progression and extrahepatic complications are poorly explored. Here, we use an integrated epigenome and transcriptome analysis of mouse NAFLD hepatocytes and identify alterations in glyoxylate metabolism, a pathway relevant in kidney damage via oxalate release-a harmful waste product and kidney ...

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