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Disseminated tumour cells from the bone marrow of early breast cancer patients: Results from an international pooled analysis

Hartkopf, Andreas D. ; Brucker, Sara Y. ; Taran, Florin-Andrei ; Harbeck, Nadia ; von Au, Alexandra ; Naume, Bjørn ; Pierga, Jean-Yves ; Hoffmann, Oliver ; Beckmann, Matthias W. ; Rydén, Lisa ; Fehm, Tanja ; Aft, Rebecca ; Solà, Montserrat ; Walter, Vincent ; Rack, Brigitte ; Schuetz, Florian ; Borgen, Elin ; Ta, Minh-Hanh ; Bittner, Ann-Kathrin ; Fasching, Peter A. ; Fernö, Mårten ; Krawczyk, Natalia ; Weilbaecher, Katherine ; Margelí, Mireia ; Hahn, Markus ; Jueckstock, Julia ; Domschke, Christoph ; Bidard, Francois-Clement ; Kasimir-Bauer, Sabine ; Schoenfisch, Birgitt ; Kurt, Ayse G. ; Wallwiener, Markus ; Gebauer, Gerhard ; Klein, Christoph A. ; Wallwiener, Diethelm ; Janni, Wolfgang ; Pantel, Klaus



Abstract

Purpose: Presence of disseminated tumour cells (DTCs) in the bone marrow (BM) has been described as a surrogate of residual disease in patients with early breast cancer (EBC). PADDY (Pooled Analysis of DTC Detection in Early Breast Cancer) is a large international analysis of pooled data that aimed to assess the prognostic impact of DTCs in patients with EBC. Experimental design: Individual ...

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