Lösslein, Anne Kathrin ; Lohrmann, Florens ; Scheuermann, Lisa ; Gharun, Kourosh ; Neuber, Jana ; Kolter, Julia ; Forde, Aaron James ; Kleimeyer, Christian ; Poh, Ying Yee ; Mack, Matthias ; Triantafyllopoulou, Antigoni ; Dunlap, Micah D. ; Khader, Shabaana A. ; Seidl, Maximilian 
; Hölscher, Alexandra ; Hölscher, Christoph ; Guan, Xue Li ; Dorhoi, Anca ; Henneke, Philipp
; Hölscher, Alexandra ; Hölscher, Christoph ; Guan, Xue Li ; Dorhoi, Anca ; Henneke, Philipp 
Abstract
The immune response to mycobacteria is characterized by granuloma formation, which features multinucleated giant cells as a unique macrophage type. We previously found that multinucleated giant cells result from Toll-like receptor-induced DNA damage and cell autonomous cell cycle modifications. However, the giant cell progenitor identity remained unclear. Here, we show that the giant cell-forming ...
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