Startseite UR

Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy

Ullah, Irfan ; Prévost, Jérémie ; Ladinsky, Mark S. ; Stone, Helen ; Lu, Maolin ; Anand, Sai Priya ; Beaudoin-Bussières, Guillaume ; Symmes, Kelly ; Benlarbi, Mehdi ; Ding, Shilei ; Gasser, Romain ; Fink, Corby ; Chen, Yaozong ; Tauzin, Alexandra ; Goyette, Guillaume ; Bourassa, Catherine ; Medjahed, Halima ; Mack, Matthias ; Chung, Kunho ; Wilen, Craig B. ; Dekaban, Gregory A. ; Dikeakos, Jimmy D. ; Bruce, Emily A. ; Kaufmann, Daniel E. ; Stamatatos, Leonidas ; McGuire, Andrew T. ; Richard, Jonathan ; Pazgier, Marzena ; Bjorkman, Pamela J. ; Mothes, Walther ; Finzi, Andrés ; Kumar, Priti ; Uchil, Pradeep D.



Zusammenfassung

Neutralizing antibodies (NAbs) are effective in treating COVID-19, but the mechanism of immune protection is not fully understood. Here, we applied live bioluminescence imaging (BLI) to monitor the real-time effects of NAb treatment during prophylaxis and therapy of K18-hACE2 mice intranasally infected with SARS-CoV-2-nanoluciferase. Real-time imaging revealed that the virus spread sequentially ...

plus


Nur für Besitzer und Autoren: Kontrollseite des Eintrags
  1. Universität

Universitätsbibliothek

Publikationsserver

Kontakt:

Publizieren: oa@ur.de
0941 943 -4239 oder -69394

Dissertationen: dissertationen@ur.de
0941 943 -3904

Forschungsdaten: datahub@ur.de
0941 943 -5707

Ansprechpartner