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Gender specific airway gene expression in COPD sub-phenotypes supports a role of mitochondria and of different types of leukocytes

Esteve-Codina, Anna ; Hofer, Thomas P. ; Burggraf, Dorothe ; Heiss-Neumann, Marion S. ; Gesierich, Wolfgang ; Boland, Anne ; Olaso, Robert ; Bihoreau, Marie-Therese ; Deleuze, Jean-Francois ; Moeller, Winfried ; Schmid, Otmar ; Soler Artigas, María ; Renner, Kathrin ; Hohlfeld, Jens M. ; Welte, Tobias ; Fuehner, Thomas ; Jerrentrup, Lukas ; Koczulla, Andreas Rembert ; Greulich, Timm ; Prasse, Antje ; Müller-Quernheim, Joachim ; Gupta, Sumit ; Brightling, Christopher ; Subramanian, Deepak R. ; Parr, David G. ; Kolsum, Umme ; Gupta, Vandana ; Barta, Imre ; Döme, Balázs ; Strausz, János ; Stendardo, Mariarita ; Piattella, Marco ; Boschetto, Piera ; Korzybski, Damian ; Gorecka, Dorota ; Nowinski, Adam ; Dabad, Marc ; Fernández-Callejo, Marcos ; Endesfelder, David ; zu Castell, Wolfgang ; Hiemstra, Pieter S. ; Venge, Per ; Noessner, Elfriede ; Griebel, Thasso ; Heath, Simon ; Singh, Dave ; Gut, Ivo ; Ziegler-Heitbrock, Loems



Zusammenfassung

Chronic obstructive pulmonary disease (COPD) is a destructive inflammatory disease and the genes expressed within the lung are crucial to its pathophysiology. We have determined the RNAseq transcriptome of bronchial brush cells from 312 stringently defined ex-smoker patients. Compared to healthy controls there were for males 40 differentially expressed genes (DEGs) and 73 DEGs for females with ...

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