National Institutes of Health Consensus Development Project on Criteria for Clinical Trials in Chronic Graft-versus-Host Disease: IIa. The 2020 Clinical Implementation and Early Diagnosis Working Group Report

Kitko, Carrie L. ; Pidala, Joseph ; Schoemans, Hélène M. ; Lawitschka, Anita ; Flowers, Mary E. ; Cowen, Edward W. ; Tkaczyk, Eric ; Farhadfar, Nosha ; Jain, Sandeep ; Steven, Philipp ; Luo, Zhonghui K. ; Ogawa, Yoko ; Stern, Michael ; Yanik, Greg A. ; Cuvelier, Geoffrey D.E. ; Cheng, Guang-Shing ; Holtan, Shernan G. ; Schultz, Kirk R. ; Martin, Paul J. ; Lee, Stephanie J. ; Pavletic, Steven Z. ; Wolff, Daniel ; Paczesny, Sophie ; Blazar, Bruce R. ; Sarantopoulos, Stephanie ; Socie, Gerard ; Greinix, Hildegard ; Cutler, Corey

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Alternative Links zum Volltext:DOIVerlag

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Details

Dokumentenart:	Artikel
Titel eines Journals oder einer Zeitschrift:	Transplantation and Cellular Therapy
Verlag:	ELSEVIER SCIENCE INC
Ort der Veröffentlichung:	NEW YORK
Band:	27
Nummer des Zeitschriftenheftes oder des Kapitels:	7
Seitenbereich:	S. 545-557
Datum:	2021
Institutionen:	Medizin > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Identifikationsnummer:	Wert Typ 10.1016/j.jtct.2021.03.033 DOI
Stichwörter / Keywords:	BRONCHIOLITIS-OBLITERANS-SYNDROME; HEMATOPOIETIC-CELL TRANSPLANTATION; MEASURING THERAPEUTIC RESPONSE; FORCED EXPIRATORY FLOW; DRY EYE; PROGNOSTIC VALUE; PREDICTIVE-VALUE; CHRONIC GVHD; RISK-FACTORS; LUNG; Chronic graft-versus-host disease; Allogeneic hematopoietic cell transplantation; Consensus; Early diagnosis
Dewey-Dezimal-Klassifikation:	600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin
Status:	Veröffentlicht
Begutachtet:	Ja, diese Version wurde begutachtet
An der Universität Regensburg entstanden:	Ja
Dokumenten-ID:	56757

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Zusammenfassung

Recognition of the earliest signs and symptoms of chronic graft-versus-host disease (GVHD) that lead to severe manifestations remains a challenge. The standardization provided by the National Institutes of Health (NIH) 2005 and 2014 consensus projects has helped improve diagnostic accuracy and severity scoring for clinical trials, but utilization of these tools in routine clinical practice is ...

Zusammenfassung

Recognition of the earliest signs and symptoms of chronic graft-versus-host disease (GVHD) that lead to severe manifestations remains a challenge. The standardization provided by the National Institutes of Health (NIH) 2005 and 2014 consensus projects has helped improve diagnostic accuracy and severity scoring for clinical trials, but utilization of these tools in routine clinical practice is variable. Additionally, when patients meet the NIH diagnostic criteria, many already have significant morbidity and possibly irreversible organ damage. The goals of this early diagnosis project are 2-fold. First, we provide consensus recommendations regarding implementation of the current NIH diagnostic guidelines into routine transplant care, outside of clinical trials, aiming to enhance early clinical recognition of chronic GVHD. Second, we propose directions for future research efforts to enable discovery of new, early laboratory as well as clinical indicators of chronic GVHD, both globally and for highly morbid organ-specific manifestations. Identification of early features of chronic GVHD that have high positive predictive value for progression to more severe manifestations of the disease could potentially allow for future pre-emptive clinical trials. (C) 2021 The American Society for Transplantation and Cellular Therapy.

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