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Genome-wide association study of asthma exacerbations despite inhaled corticosteroid use

Hernandez-Pacheco, Natalia ; Vijverberg, Susanne J. ; Herrera-Luis, Esther ; Li, Jiang ; Sio, Yang Yie ; Granell, Raquel ; Corrales, Almudena ; Maroteau, Cyrielle ; Lethem, Ryan ; Perez-Garcia, Javier ; Farzan, Niloufar ; Repnik, Katja ; Gorenjak, Mario ; Soares, Patricia ; Karimi, Leila ; Schieck, Maximilian ; Pérez-Méndez, Lina ; Berce, Vojko ; Tavendale, Roger ; Eng, Celeste ; Sardon, Olaia ; Kull, Inger ; Mukhopadhyay, Somnath ; Pirmohamed, Munir ; Verhamme, Katia M.C. ; Burchard, Esteban G. ; Kabesch, Michael ; Hawcutt, Daniel B. ; Melén, Erik ; Potočnik, Uroš ; Chew, Fook Tim ; Tantisira, Kelan G. ; Turner, Steve ; Palmer, Colin N. ; Flores, Carlos ; Pino-Yanes, Maria ; Maitland-van der Zee, Anke H.



Zusammenfassung

Rationale: Substantial variability in response to asthma treatment with inhaled corticosteroids (ICS) has been described among individuals and populations, suggesting the contribution of genetic factors. Nonetheless, only a few genes have been identified to date. We aimed to identify genetic variants associated with asthma exacerbations despite ICS use in European children and young adults and to ...

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