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Identification of ROBO2 as a Potential Locus Associated with Inhaled Corticosteroid Response in Childhood Asthma

Hernandez-Pacheco, Natalia ; Gorenjak, Mario ; Li, Jiang ; Repnik, Katja ; Vijverberg, Susanne J. ; Berce, Vojko ; Jorgensen, Andrea ; Karimi, Leila ; Schieck, Maximilian ; Samedy-Bates, Lesly-Anne ; Tavendale, Roger ; Villar, Jesús ; Mukhopadhyay, Somnath ; Pirmohamed, Munir ; Verhamme, Katia M. C. ; Kabesch, Michael ; Hawcutt, Daniel B. ; Turner, Steve ; Palmer, Colin N. ; Tantisira, Kelan G. ; Burchard, Esteban G. ; Maitland-van der Zee, Anke H. ; Flores, Carlos ; Potočnik, Uroš ; Pino-Yanes, Maria



Zusammenfassung

Inhaled corticosteroids (ICS) are the most common asthma controller medication. An important contribution of genetic factors in ICS response has been evidenced. Here, we aimed to identify novel genetic markers involved in ICS response in asthma. A genome-wide association study (GWAS) of the change in lung function after 6 weeks of ICS treatment was performed in 166 asthma patients from the ...

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