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Estrogen deficiency during puberty affects the expression of microRNA30a and microRNA503 in the mandibular condyle

Bergamo, Ana Zilda Nazar ; Madalena, Isabela Ribeiro ; Omori, Marjorie Ayumi ; Ramazzotto, Lucas Alexandre ; Nelson-Filho, Paulo ; Baratto-Filho, Flares ; Proff, Peter ; Kirschneck, Christian ; Küchler, Erika Calvano


Background: The aim of this study was investigated if estrogen deficiency during puberty affects the expression of miRNA30a and miRNA503 in maxillary and mandibular growth centers, and also evaluated if ER alpha and ER beta are correlated with miRNA30a and miRNA503 expressions. Methods: Samples from 12 female Wistar rats randomized into experimental group (OVX) and control group (SHAM). At an age ...


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