ArthroRad trial: multicentric prospective and randomized single-blinded trial on the effect of low-dose radiotherapy for painful osteoarthritis depending on the dose—results after 3 months’ follow-up

URN to cite this document:

urn:nbn:de:bvb:355-epub-569002 Copy

DOI to cite this document:

10.5283/epub.56900 Copy

Niewald, Marcus ; Müller, Lara Natalie ; Hautmann, Matthias G. ; Dzierma, Yvonne ; Melchior, Patrick ; Gräber, Stefan ; Rübe, Christian ; Fleckenstein, Jochen

License: Creative Commons Attribution 4.0 PDF - Published Version (1MB)

Date of publication of this fulltext: 29 Feb 2024 12:42

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Details

Item type:	Article
Open Access Type:	DEAL (Springer) - Non UR
Journal or Publication Title:	Strahlentherapie und Onkologie
Publisher:	Springer
Place of Publication:	HEIDELBERG
Volume:	198
Number of Issue or Book Chapter:	4
Page Range:	pp. 370-377
Date:	1 November 2021
Institutions:	Medicine > Lehrstuhl für Strahlentherapie
Identification Number:	Value Type 10.1007/s00066-021-01866-2 DOI
Keywords:	INFLAMMATION; SCORE; Osteoarthritis; Radiotherapy; Low dose; Pain relief; Quality of life
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	56900

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Abstract

Purpose Randomized comparison of the effect of radiotherapy on painful osteoarthritis (OA) applying a standard-dose vs. a very-low-dose regime Patients and methods Patients with OA of the hand and knee joints were included. Further inclusion criteria: symptoms for more than 3 months, favorable general health status, age above 40 years. Patients with prior local radiotherapy, trauma, ...

Abstract

Purpose
Randomized comparison of the effect of radiotherapy on painful osteoarthritis (OA) applying a standard-dose vs. a very-low-dose regime

Patients and methods
Patients with OA of the hand and knee joints were included. Further inclusion criteria: symptoms for more than 3 months, favorable general health status, age above 40 years. Patients with prior local radiotherapy, trauma, rheumatoid arthritis, or vascular diseases were excluded. After randomization (every joint was randomized separately), the following protocols were applied: standard arm: total dose 3.0 Gy, single fractions of 0.5 Gy twice weekly; experimental arm: total dose 0.3 Gy, single fractions of 0.05 Gy twice weekly. The dosage was not known to the patients. The patients were examined 3 and 12 months after radiotherapy. Scores like VAS (visual analogue scale), KOOS-SF (the knee injugy and osteoarthritis outcome score), SF-SACRAH (short form score for the assessment and quantification of chronic rheumatic affections of the hands), and SF-12 (short form 12) were used.

Results
A total of 64 knees and 172 hands were randomized. 3.0 Gy was applied to 87 hands and 34 knees, 0.3 Gy was given to 85 hands and 30 knees. After 3 months, we observed good pain relief after 3 Gy and after 0.3 Gy, there was no statistically significant difference. Side effects were not recorded. The trial was closed prematurely due to slow recruitment.

Conclusion
We found favorable pain relief and a limited response in the functional and quality of life scores in both arms. The effect of low doses such as 0.3 Gy on pain is widely unknown. Further trials are necessary to compare a conventional dose to placebo and to further explore the effect of low doses on inflammatory disorders.

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Metadata last modified: 12 Sep 2024 05:00

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