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GSTM1 and GSTT1 double null genotypes determining cell fate and proliferation as potential risk factors of relapse in children with hematological malignancies after hematopoietic stem cell transplantation

Jurkovic Mlakar, Simona ; Uppugunduri, Satyanarayana Chakradhara Rao ; Nava, Tiago ; Mlakar, Vid ; Golay, Hadrien ; Robin, Shannon ; Waespe, Nicolas ; Rezgui, Mohamed Aziz ; Chalandon, Yves ; Boelens, Jaap Jan ; Bredius, Robert G. M. ; Dalle, Jean-Hugues ; Peters, Christina ; Corbacioglu, Selim ; Bittencourt, Henrique ; Krajinovic, Maja ; Ansari, Marc



Abstract

Purpose This study aimed to retrospectively evaluate the genetic association of null variants of glutathione S-transferases GSTM1 and GSTT1 with relapse incidence in children with hematological malignancies (HMs) undergoing busulfan (BU)- containing allogeneic hematopoietic stem cell transplantation (HSCT) and to assess the impact of these variants on BU-induced cytotoxicity on the immortalized ...

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