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Mouthrinses against SARS-CoV-2 – High antiviral effectivity by membrane disruption in vitro translates to mild effects in a randomized placebo-controlled clinical trial

Meister, Toni Luise ; Gottsauner, Josef-Maximilian ; Schmidt, Barbara ; Heinen, Natalie ; Todt, Daniel ; Audebert, Franz ; Buder, Felix ; Lang, Henriette ; Gessner, André ; Steinmann, Eike ; Vielsmeier, Veronika ; Pfaender, Stephanie ; Cieplik, Fabian


The emergence of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) represents an unprecedented threat for the human population, necessitating rapid and effective intervention measures. Given the main infection route by airborne transmission, significant attention has been bestowed upon the use of antiseptic mouthrinses as a way to possibly reduce infectious viral titers. However, ...


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