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Biomodulatory therapy induces durable remissions in multi-system Langerhans cell histiocytosis

Harrer, Dennis C. ; Jakob, Marcus ; Vogelhuber, Martin ; Lüke, Florian ; Utpatel, Kirsten ; Corbacioglu, Selim ; Herr, Wolfgang ; Reichle, Albrecht ; Heudobler, Daniel


Langerhans cell histiocytosis (LCH) is rare hematological neoplasia originating from the aberrant proliferation of CD207-positive dendritic cells. Refractory multi-system LCH is difficult to treat necessitating the continuous development of different salvage therapies. At our medical center, eleven patients (age 11 months to 77 years) with multi-system LCH were treated on a compassionate use ...


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