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Propionate induces cross-tolerance to TLR1/2 and TLR4 agonists in an IFIT-dependent manner

Fischer, Christina ; Weber-Steffens, Dorothea ; Kreutz, Marina ; Hehlgans, Thomas



Abstract

In this study, we have identified Interferon-stimulated genes (ISGs), especially IFIT1, 2 and 3, as target genes of propionate-induced signalling in the human epithelial cell line A549, the monocytic cell line THP-1 as well as in primary, human peripheral blood-derived macrophages (PBMs). Induction of the IFIT gene family by propionate negatively regulates TLR-induced signalling. Propionate ...

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