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Physical-chemical and toxicological properties of osmolyte-based cationic surfactants and spontaneously formed low-toxic catanionic vesicles out of them

Müller, Eva ; Drechsler, Markus ; Klein, Regina ; Heilmann, J. ; Estrine, Boris ; Kunz, Werner


In the context of efficient drug delivery systems, catanionic vesicles offer several advantages, such as spontaneous formation and long-term stability. However, especially the cationic component of such vesicles is often toxic. Thus, the search for less toxic, biocompatible amphiphiles, while maintaining the desirable aggregation properties is crucial. In this work, we present cytotoxicity ...


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