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Shortened Hinge Design of Fab x sdAb-Fc Bispecific Antibodies Enhances Redirected T-Cell Killing of Tumor Cells

Huang, Shuyu ; Segués, Aina ; Waterfall, Martin ; Wright, David ; Vayssiere, Charlotte ; van Duijnhoven, Sander M. J. ; van Elsas, Andrea ; Sijts, Alice J. A. M. ; Zaiss, Dietmar M.


T cell engager (TCE) antibodies have emerged as promising cancer therapeutics that link cytotoxic T-cells to tumor cells by simultaneously binding to CD3E on T-cells and to a tumor-associated antigen (TAA) expressed by tumor cells. We previously reported a novel bispecific format, the IgG-like Fab x sdAb-Fc (also known as half-IG_VH-h-CH2-CH3), combining a conventional antigen-binding fragment ...


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