IL12 integrated into the CAR exodomain converts CD8+ T cells to poly-functional NK-like cells with superior killing of antigen-loss tumors
Hombach, Andreas, Barden, Markus, Hannappel, Lisa, Chmielewski, Markus, Rappl, Gunter, Sachinidis, Agapios and Abken, Hinrich (2022) IL12 integrated into the CAR exodomain converts CD8+ T cells to poly-functional NK-like cells with superior killing of antigen-loss tumors. Molecular Therapy 30 (2), pp. 593-605.Date of publication of this fulltext: 29 Feb 2024 12:47
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| Item type | Article | ||||
| Journal or Publication Title | Molecular Therapy | ||||
| Publisher: | CELL PRESS | ||||
|---|---|---|---|---|---|
| Place of Publication: | CAMBRIDGE | ||||
| Volume: | 30 | ||||
| Number of Issue or Book Chapter: | 2 | ||||
| Page Range: | pp. 593-605 | ||||
| Date | 2022 | ||||
| Institutions | Leibniz Institute for Immunotherapy (LIT) | ||||
| Identification Number |
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| Keywords | INDUCED KILLER-CELLS; HLA-E EXPRESSION; PHASE-I TRIAL; CD28 COSTIMULATION; ANTITUMOR-ACTIVITY; CHIMERIC RECEPTOR; RETROVIRAL VECTOR; FUSION PROTEIN; SPACER DOMAIN; GENE-THERAPY | ||||
| Dewey Decimal Classification | 600 Technology > 610 Medical sciences Medicine | ||||
| Status | Published | ||||
| Refereed | Yes, this version has been refereed | ||||
| Created at the University of Regensburg | Yes | ||||
| Item ID | 57081 |
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