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Emerging Role of EGFR Mutations in Creating an Immune Suppressive Tumour Microenvironment

Kapoor, Simran S. ; Zaiss, Dietmar M. W.



Abstract

Several types of tumours overexpress the Epidermal Growth Factor Receptor (EGFR) in either wild type or mutated form. These tumours are often highly aggressive and difficult to treat. The underlying mechanisms for this phenomenon have remained largely unresolved, but recent publications suggest two independent mechanisms that may contribute. According to one line of research, tumours that ...

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