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Structure of the NLRP3 decamer bound to the cytokine release inhibitor CRID3

Hochheiser, Inga V. ; Pilsl, Michael ; Hagelueken, Gregor ; Moecking, Jonas ; Marleaux, Michael ; Brinkschulte, Rebecca ; Latz, Eicke ; Engel, Christoph ; Geyer, Matthias



Abstract

NLRP3 is an intracellular sensor protein that when activated by a broad spectrum of exogenous and endogenous stimuli leads to inflammasome formation and pyroptosis(1,2). The conformational states of NLRP3 and the way antagonistic small molecules act at the molecular level remain poorly understood(2,3). Here we report the cryo-electron microscopy structures of full-length human NLRP3 in its native ...

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