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Influence of Anoctamin-4 and -9 on ADAM10 and ADAM17 Sheddase Function

Leitzke, Sinje ; Seidel, Jana ; Ahrens, Björn ; Schreiber, Rainer ; Kunzelmann, Karl ; Sperrhacke, Maria ; Bhakdi, Sucharit ; Reiss, Karina


Ca2+-activated Cl- channels (TMEM16, also known as anoctamins) perform important functions in cell physiology, including modulation of cell proliferation and cancer growth. Many members, including TMEM16F/ANO6, additionally act as Ca2+-activated phospholipid scramblases. We recently presented evidence that ANO6-dependent surface exposure of phosphatidylserine (PS) is pivotal for the ...


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