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Transcription factor Zfp276 drives oligodendroglial differentiation and myelination by switching off the progenitor cell program

Aberle, Tim ; Piefke, Sandra ; Hillgärtner, Simone ; Tamm, Ernst R ; Wegner, Michael ; Küspert, Melanie



Abstract

In oligodendrocytes of the vertebrate central nervous system a complex network of transcriptional regulators is required to ensure correct and timely myelination of neuronal axons. Here we identify Zfp276, the only mammalian ZAD-domain containing zinc finger protein, as a transcriptional regulator of oligodendrocyte differentiation and central myelination downstream of Sox10. In the central ...

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