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Equilibria between conformational states of the Ras oncogene protein revealed by high pressure crystallography

Girard, Eric ; Lopes, Pedro ; Spoerner, Michael ; Dhaussy, Anne-Claire ; Prangé, Thierry ; Kalbitzer, Hans Robert ; Colloc'h, Nathalie



Abstract

In this work, we experimentally investigate the allosteric transitions between conformational states on the Ras oncogene protein using high pressure crystallography. Ras protein is a small GTPase involved in central regulatory processes occurring in multiple conformational states. Ras acts as a molecular switch between active GTP-bound, and inactive GDP-bound states, controlling essential signal ...

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