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Early and Long-Term HIV-1 Immunogenicity Induced in Macaques by the Combined Administration of DNA, NYVAC and Env Protein-Based Vaccine Candidates: The AUP512 Study

Perdiguero, Beatriz ; Asbach, Benedikt ; Gómez, Carmen E. ; Köstler, Josef ; Barnett, Susan W. ; Koutsoukos, Marguerite ; Weiss, Deborah E. ; Cristillo, Anthony D. ; Foulds, Kathryn E. ; Roederer, Mario ; Montefiori, David C. ; Yates, Nicole L. ; Ferrari, Guido ; Shen, Xiaoying ; Sawant, Sheetal ; Tomaras, Georgia D. ; Sato, Alicia ; Fulp, William J. ; Gottardo, Raphael ; Ding, Song ; Heeney, Jonathan L. ; Pantaleo, Giuseppe ; Esteban, Mariano ; Wagner, Ralf



Zusammenfassung

To control HIV infection there is a need for vaccines to induce broad, potent and long-term B and T cell immune responses. With the objective to accelerate and maintain the induction of substantial levels of HIV-1 Env-specific antibodies and, at the same time, to enhance balanced CD4 and CD8 T cell responses, we evaluated the effect of concurrent administration of MF59-adjuvanted Env protein ...

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