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Decitabine-Mediated Upregulation of CSPG4 in Ovarian Carcinoma Cells Enables Targeting by CSPG4-Specific CAR-T Cells

Harrer, Dennis Christoph ; Schenkel, Charlotte ; Berking, Carola ; Herr, Wolfgang ; Abken, Hinrich ; Dörrie, Jan ; Schaft, Niels


Simple Summary Cancer therapy by specifically redirected T cells has revolutionized the field of oncology. However, the repertoire of targetable antigens is small. Here, we use the FDA-approved drug decitabine to upregulate the surface antigen CSPG4 on CSPG4-negative ovarian carcinoma cells. By optimizing decitabine dosing, we converted more than 50% of treated ovarian carcinoma cells to ...


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