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Urea transporter-B expression on the ocular surface and in the lacrimal glands

Jäger, Franziska ; Paulsen, Friedrich ; Bergua, Antonio ; Jungbauer, Rebecca ; Hammer, Christian M.



Abstract

Objective: Urea is a component of tear fluid showing a significantly decreased concentration in dry eye disease. The urea content of tear fluid may depend on urea transporters. The purpose of this study was to examine the expression of urea transporter B (UT-B) at the ocular surface and in the lacrimal glands. Methods: UT-B protein and mRNA expression was investigated in human, porcine, and ...

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