Spire1 and Myosin Vc promote Ca2+-evoked externalization of von Willebrand factor in endothelial cells

URN to cite this document:: urn:nbn:de:bvb:355-epub-574105
DOI to cite this document:: 10.5283/epub.57410

Holthenrich, Anna ; Terglane, Julian ; Naß, Johannes ; Mietkowska, Magdalena ; Kerkhoff, Eugen ; Gerke, Volker

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Date of publication of this fulltext: 29 Feb 2024 12:55

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Abstract

Weibel-Palade bodies (WPB) are endothelial cell-specific storage granules that regulate vascular hemostasis by releasing the platelet adhesion receptor von Willebrand factor (VWF) following stimulation. Fusion of WPB with the plasma membrane is accompanied by the formation of actin rings or coats that support the expulsion of large multimeric VWF fibers. However, factor(s) organizing these actin ...