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Deficiency in Retinal TGFβ Signaling Aggravates Neurodegeneration by Modulating Pro-Apoptotic and MAP Kinase Pathways

Bielmeier, Christina B. ; Schmitt, Sabrina I. ; Kleefeldt, Nikolai ; Boneva, Stefaniya K. ; Schlecht, Anja ; Vallon, Mario ; Tamm, Ernst R. ; Hillenkamp, Jost ; Ergün, Süleyman ; Neueder, Andreas ; Braunger, Barbara M.


Transforming growth factor beta (TGF beta) signaling has manifold functions such as regulation of cell growth, differentiation, migration, and apoptosis. Moreover, there is increasing evidence that it also acts in a neuroprotective manner. We recently showed that TGF beta receptor type 2 (Tgfbr2) is upregulated in retinal neurons and Muller cells during retinal degeneration. In this study we ...


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