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Immunohistochemical detection of urea transporter-A in the tear-producing part of the lacrimal system

Jäger, Franziska ; Paulsen, Friedrich ; Bergua, Antonio ; Jungbauer, Rebecca ; Hammer, Christian M.



Abstract

Objective: Urea constitutes a physiological and presumably well-regulated constituent of tear fluid. Its la-crimal concentration is significantly decreased in dry eye disease. Urea homeostasis within the tear fluid may also depend on the expression of urea transporters. The present study reports on the expression patterns of urea transporter A (UT-A) in the cells and tissues of the ocular surface ...

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