Go to content
UR Home

ATG9A prevents TNF cytotoxicity by an unconventional lysosomal targeting pathway

Huyghe, Jon ; Priem, Dario ; Van Hove, Lisette ; Gilbert, Barbara ; Fritsch, Jürgen ; Uchiyama, Yasuo ; Hoste, Esther ; van Loo, Geert ; Bertrand, Mathieu J. M.


Cell death induced by tumor necrosis factor (TNF) can be beneficial during infection by helping to mount proper immune responses. However, TNF-induced death can also drive a variety of inflammatory pathologies. Protectives brakes, or cell-death checkpoints, normally repress TNF cytotoxicity to protect the organism from its potential detrimental consequences. Thus, although TNF can kill, this only ...


Owner only: item control page
  1. Homepage UR

University Library

Publication Server


Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: datahub@ur.de
0941 943 -5707

Contact persons