The PI3K inhibitor pictilisib and the multikinase inhibitors pazopanib and sorafenib have an impact on Rac1 level and migration of medulloblastoma in vitro

URN to cite this document:: urn:nbn:de:bvb:355-epub-574402
DOI to cite this document:: 10.5283/epub.57440

Schoen, Leonie F. ; Craveiro, Rogerio B. ; Pietsch, Torsten ; Moritz, Thomas ; Troeger, Anja ; Jordans, Silvia ; Dilloo, Dagmar

License: Creative Commons Attribution 4.0
PDF - Published Version
(5MB)

Date of publication of this fulltext: 29 Feb 2024 12:56

Alternative links to fulltext:DOI Publisher

Details

Preview

Indexed in

Export bibliographical data

Abstract

Metastatic disease is the leading cause of death in children suffering from medulloblastoma and a major treatment challenge. The evidence of leptomeningeal dissemination defines the most aggressive tumours and is associated with increased mortality; thus, inhibition of migration as a factor involved in the process of metastatic disease is fundamental for the treatment and prevention of metastatic ...