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The PI3K inhibitor pictilisib and the multikinase inhibitors pazopanib and sorafenib have an impact on Rac1 level and migration of medulloblastoma in vitro

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Schoen, Leonie F. ; Craveiro, Rogerio B. ; Pietsch, Torsten ; Moritz, Thomas ; Troeger, Anja ; Jordans, Silvia ; Dilloo, Dagmar
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Date of publication of this fulltext: 29 Feb 2024 12:56


Metastatic disease is the leading cause of death in children suffering from medulloblastoma and a major treatment challenge. The evidence of leptomeningeal dissemination defines the most aggressive tumours and is associated with increased mortality; thus, inhibition of migration as a factor involved in the process of metastatic disease is fundamental for the treatment and prevention of metastatic ...


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