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The PI3K inhibitor pictilisib and the multikinase inhibitors pazopanib and sorafenib have an impact on Rac1 level and migration of medulloblastoma in vitro

URN to cite this document:
urn:nbn:de:bvb:355-epub-574402
DOI to cite this document:
10.5283/epub.57440
Schoen, Leonie F. ; Craveiro, Rogerio B. ; Pietsch, Torsten ; Moritz, Thomas ; Troeger, Anja ; Jordans, Silvia ; Dilloo, Dagmar
[img]License: Creative Commons Attribution 4.0
PDF - Published Version
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Date of publication of this fulltext: 29 Feb 2024 12:56



Abstract

Metastatic disease is the leading cause of death in children suffering from medulloblastoma and a major treatment challenge. The evidence of leptomeningeal dissemination defines the most aggressive tumours and is associated with increased mortality; thus, inhibition of migration as a factor involved in the process of metastatic disease is fundamental for the treatment and prevention of metastatic ...

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