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As in Real Estate, Location Matters: Cellular Expression of Complement Varies Between Macular and Peripheral Regions of the Retina and Supporting Tissues

Zauhar, Randy ; Biber, Josef ; Jabri, Yassin ; Kim, Mijin ; Hu, Jian ; Kaplan, Lew ; Pfaller, Anna M. ; Schäfer, Nicole ; Enzmann, Volker ; Schlötzer-Schrehardt, Ursula ; Straub, Tobias ; Hauck, Stefanie M. ; Gamlin, Paul D. ; McFerrin, Michael B. ; Messinger, Jeffrey ; Strang, Christianne E. ; Curcio, Christine A. ; Dana, Nicholas ; Pauly, Diana ; Grosche, Antje ; Li, Mingyao ; Stambolian, Dwight


The cellular events that dictate the initiation of the complement pathway in ocular degeneration, such as age-related macular degeneration (AMD), is poorly understood. Using gene expression analysis (single cell and bulk), mass spectrometry, and immunohistochemistry, we dissected the role of multiple retinal and choroidal cell types in determining the complement homeostasis. Our scRNA-seq data ...


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