Go to content
UR Home

Expression of TRX1 optimizes the antitumor functions of human CAR T cells and confers resistance to a pro-oxidative tumor microenvironment

Balta, Emre ; Janzen, Nina ; Kirchgessner, Henning ; Toufaki, Vasiliki ; Orlik, Christian ; Liang, Jie ; Lairikyengbam, Divya ; Abken, Hinrich ; Niesler, Beate ; Müller-Decker, Karin ; Ruppert, Thomas ; Samstag, Yvonne


Use of chimeric antigen receptor (CAR) T cells to treat B cell lymphoma and leukemia has been remarkably successful. Unfortunately, the therapeutic efficacy of CAR T cells against solid tumors is very limited, with immunosuppression by the pro-oxidative tumor microenvironment (TME) a major contributing factor. High levels of reactive oxygen species are well-tolerated by tumor cells due to their ...


Owner only: item control page
  1. Homepage UR

University Library

Publication Server


Publishing: oa@ur.de
0941 943 -4239 or -69394

Dissertations: dissertationen@ur.de
0941 943 -3904

Research data: datahub@ur.de
0941 943 -5707

Contact persons