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Global effects of pharmacologic inhibition of OSBP in human umbilical vein endothelial cells

Taskinen, Juuso H. ; Ruhanen, Hanna ; Matysik, Silke ; Käkelä, Reijo ; Olkkonen, Vesa M.



Abstract

Oxysterol-binding protein (OSBP) is a cholesterol/PI4P exchanger at contacts of the endoplasmic reticulum (ER) with trans-Golgi network (TGN) and endosomes. Several central endothelial cell (EC) functions depend on adequate cholesterol distribution in cellular membranes. Here we elucidated the effects of pharmacologic OSBP inhibition on the lipidome and transcriptome of human umbilical vein ...

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