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GOLM1 depletion modifies cellular sphingolipid metabolism and adversely affects cell growth

Nagaraj, Meghana ; Höring, Marcus ; Ahonen, Maria A. ; Nguyen, Van Dien ; Zhou, You ; Vihinen, Helena ; Jokitalo, Eija ; Liebisch, Gerhard ; Nidhina Haridas, P.A. ; Olkkonen, Vesa M.



Abstract

Golgi membrane protein 1 (GOLM1) is a Golgi-resident type 2 transmembrane protein known to be overexpressed in several cancers, including he-patocellular carcinoma (HCC), as well as in viral in-fections. However, the role of GOLM1 in lipid metabolism remains enigmatic. In this study, we employed siRNA-mediated GOLM1 depletion in Huh -7 HCC cells to study the role of GOLM1 in lipid metabolism. ...

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