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Selonsertib in adults with pulmonary arterial hypertension (ARROW): a randomised, double-blind, placebo-controlled, phase 2 trial

Rosenkranz, Stephan ; Feldman, Jeremy ; McLaughlin, Vallerie V ; Rischard, Franz ; Lange, Tobias J ; White, R James ; Peacock, Andrew J ; Gerhardt, Felix ; Ebrahimi, Ramin ; Brooks, Gabriel ; Satler, Carol ; Frantz, Robert P



Abstract

Background Data obtained in human lung tissue and preclinical models suggest that oxidative stress and increased apoptosis signal-regulating kinase 1 (ASK1) activity might have a prominent role in the pathobiology of pulmonary arterial hypertension (PAH). The purpose of this study was to determine the efficacy, safety, and tolerability of the ASK1 inhibitor selonsertib compared with placebo in ...

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