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Mutations in the osteoprotegerin-encoding gene are associated with temporomandibular joint ankylosis

Corso, Paola Fernanda ; Machado, Renato Assis ; Gerber, Jennifer Tsi ; Deliberador, Tatiana Miranda ; Costa, Davani Latarullo ; Klüppel, Leandro Eduardo ; Rebellato, Nelson Luis Barbosa ; Brancher, João Armando ; Küchler, Erika Calvano ; Coletta, Ricardo D. ; Scariot, Rafaela


Objective. This study aimed to investigate genetic variations in the osteoprotegerin-encoding gene (TNFRSF11B) in patients with temporomandibular joint ankylosis (TMJA). Study design. The sample comprised 17 patients diagnosed with TMJA, of both sexes with ages ranging from 6 to 57 years old. TNFRSF11B mutational analysis was performed using the Sanger sequencing method with DNA extracted from ...


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