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High expression of ERBB2 is an independent risk factor for reduced recurrence-free survival in patients with stage T1 non-muscle-invasive bladder cancer

Sikic, Danijel ; Eckstein, Markus ; Weyerer, Veronika ; Kubon, Jennifer ; Breyer, Johannes ; Roghmann, Florian ; Kunath, Frank ; Keck, Bastian ; Erben, Philipp ; Hartmann, Arndt ; Wirtz, Ralph M. ; Wullich, Bernd ; Taubert, Helge ; Wach, Sven


Introduction: Molecular markers associated with breast cancer are assumed to be associated with outcome in non-muscle-invasive bladder cancer (NMIBC). Materials and methods: We retrospectively investigated the association of the mRNA expression of estrogen receptor 1 (ESR1) and 2 (ESR2), progesterone receptor (PGR), MKI67, and HER2 (ERBB2) with recurrence-free (RFS), cancer-specific (CSS), and ...


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