Dokumentenart: | Artikel | ||||
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Titel eines Journals oder einer Zeitschrift: | Transplantation and Cellular Therapy | ||||
Verlag: | ELSEVIER SCIENCE INC | ||||
Ort der Veröffentlichung: | NEW YORK | ||||
Band: | 28 | ||||
Nummer des Zeitschriftenheftes oder des Kapitels: | 8 | ||||
Seitenbereich: | S. 426-445 | ||||
Datum: | 2022 | ||||
Institutionen: | Medizin > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) Medizin > Abteilung für Nephrologie Medizin > Lehrstuhl für Neurologie | ||||
Identifikationsnummer: |
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Stichwörter / Keywords: | STEM-CELL TRANSPLANTATION; AUTOIMMUNE HEMOLYTIC-ANEMIA; CENTRAL-NERVOUS-SYSTEM; BONE-MARROW-TRANSPLANTATION; CORD BLOOD TRANSPLANTATION; TUBULAR BRUSH-BORDER; CD4(+) T-CELLS; CHRONIC GVHD; THROMBOTIC MICROANGIOPATHY; NEUROLOGIC COMPLICATIONS; Chronic graft-versus-host disease; Atypical; National Institutes of Health Consensus Project Task Force | ||||
Dewey-Dezimal-Klassifikation: | 600 Technik, Medizin, angewandte Wissenschaften > 610 Medizin | ||||
Status: | Veröffentlicht | ||||
Begutachtet: | Ja, diese Version wurde begutachtet | ||||
An der Universität Regensburg entstanden: | Ja | ||||
Dokumenten-ID: | 57587 |
Zusammenfassung
Alloreactive and autoimmune responses after allogeneic hematopoietic cell transplantation can occur in nonclas-sical chronic graft-versus-host disease (chronic GVHD) tissues and organ systems or manifest in atypical ways in classical organs commonly affected by chronic GVHD. The National Institutes of Health (NIH) consensus projects were developed to improve understanding and classification of ...
Zusammenfassung
Alloreactive and autoimmune responses after allogeneic hematopoietic cell transplantation can occur in nonclas-sical chronic graft-versus-host disease (chronic GVHD) tissues and organ systems or manifest in atypical ways in classical organs commonly affected by chronic GVHD. The National Institutes of Health (NIH) consensus projects were developed to improve understanding and classification of the clinical features and diagnostic criteria for chronic GVHD. Although still speculative whether atypical manifestations are entirely due to chronic GVHD, these manifestations remain poorly captured by the current NIH consensus project criteria. Examples include chronic GVHD impacting the hematopoietic system as immune mediated cytopenias, endothelial dysfunction, or as atypi-cal features in the musculoskeletal system, central and peripheral nervous system, kidneys, and serous mem-branes. These purported chronic GVHD features may contribute significantly to patient morbidity and mortality. Most of the atypical chronic GVHD features have received little study, particularly within multi-institutional and prospective studies, limiting our understanding of their frequency, pathogenesis, and relation to chronic GVHD. This NIH consensus project task force report provides an update on what is known and not known about the atyp-ical manifestations of chronic GVHD while outlining a research framework for future studies to be undertaken within the next 3 to 7 years. We also provide provisional diagnostic criteria for each atypical manifestation, along with practical investigation strategies for clinicians managing patients with atypical chronic GVHD features. (c) 2022 The American Society for Transplantation and Cellular Therapy. Published by Elsevier Inc. All rights reserved.
Metadaten zuletzt geändert: 29 Feb 2024 12:58